Bone fractures in children with celiac disease: analysis of clinical and anthropometric measurements and bone metabolism markers

Introduction . Abnormal bone remodelling process is one of the clinical manifestations celiac disease, which increases risk developing osteopenia conditions, including fractures. The median age for first fracture similar in disease and general population, but incidence higher patients with disease. Aim To compare anamnestic characteristics, anthropometric measurements laboratory test results children adolescents without Materials methods A total 151 aged 1-17 years were included study. Patients divided into two groups: those who had fractures their lifetime - 21 (13.9%) no 130 (86.1%) children. Results. frequency among study was 13.9%, while vitamin D deficiency reported 2.7 times more often than its optimal level (p = 0.019). Vitamin detected 20 (95.2%) fractures, levels 30 ng/ml or found 1 (4.8%) child. In group 25(OH)D observed 43 (33.1%) cases. It that a significantly lower osteocalcin 26.9 (15.6; 32.9) < 0.001), C-terminal telopeptide 1.9 0.01). PTH concentration 34.6 (19.6; 54.7) pg/ml, whereas it 24.2 (17.1; 39.5) pg/ml 0.1). Conclusion Due to elevated severe deficiency, predominance osteoresorption over osteosynthesis tubular bones. important maintain monitor biochemical markers metabolism assess processes formation resorption.